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Item stored refrigerated! Choose correct shipping option to avoid delays. Item may not arrive cold/frozen despite our insulated system and ice packs; just cool enough to be put safe in the fridge/freezer upon arrival. Read shipping rules. No refund would be made based on this premise. If in Montreal, be sure to add gel packs (click on search and look for GELMTL). It's your decision how many gel packs you want in your order.
Basic Functions of Hyaluronic Acid
As Hyaluronic Acid is present in every tissue of the body; hyaluronic acid’s importance cannot be underestimated. Retention of water is one of the most important biological functions of hyaluronic acid, second only to providing nutrients and removing waste from cells that do not have a direct blood supply, such as cartilage cells. With a lower than adequate amount of hyaluronic acid, nutrients cannot be moved into these cells and waste cannot be eliminated from cells. Hyaluronic acid is sometimes abbreviated as HA. Hyaluronic acid is found in the synovial joint fluid, the vitreous humor of the eye, the cartilage, blood vessels, extra cellular matrix, skin and the umbilical cord
Hyaluronic Acid is Found in Synovial Joint Fluid
Our joints (like the elbows and knees) are surrounded by a membrane called the synovial membrane, which forms a capsule around the ends of the bones. This membrane secretes a liquid called the synovial fluid. Basically, the synovial fluid is found in joint cavities. It has many functions, including serving as a lubricant, shock absorber and a nutrient carrier. The fluid protects the joints and bones. Cartilage is immersed in the synovial fluid and is a fibrous connective tissue. Cartilage is avascular, meaning it contains no blood vessels. This is why the synovial fluid is so important. Synovial fluid is the only way in which nutrients can be carried into the cartilage and waste can be removed.
Hyaluronic Acid is a Key Component of Cartilage
Cartilage is a specialized form of connective tissue. Hyaline cartilage is the most predominant form of cartilage in the body. It lends strength and flexibility to the body. A key component of cartilage is hyaluronic acid. Cartilage is also avascular – with no blood vessels. Nutrients are brought by the synovial fluid, which is rich in hyaluronic acid to the cartilage, which is also hyaluronic acid rich.
HYA-300 in the Skin
In the skin, the extracellular matrix is composed of hyaluronic acid and other sulfated GAGs, combined with collagen and elastin. Large amounts of water are held in the ECM. When elastin is not bathed in water, it becomes dry and brittle, thus the look of dry, brittle, wrinkled skin. Half-life is defined as the time required for one half of the total amount of a particular substance to be consumed, broken down, or depleted. The half-life of HA in the cartilage is 2-3 weeks. But the half-life of hyaluronic acid in the skin is less than 1 day! HA is present in both the dermis and the epidermis. 50% of the body’s naturally produced hyaluronic acid that is found in the epidermis is metabolized and excreted in less than 24 hours. Like hyaluronic acid produced in the body, hyaluronic acid taken as a nutritional supplement moisturizes from the dermis to the epidermis – from deeper layers of the skin to the outer layer. The extracellular matrix fills up the space between the skin cells. This makes the skin soft, smooth and elastic. But as we age, hyaluronic content in the skin changes due to two separate clinically proven factors. There is a decrease in synthesis of hyaluronic acid. Recompartmentalization – from the epidermis to the dermis. Both changes leave the epidermis depleted in hyaluronic acid resulting in thinning, aging, and decreased moisture in the skin.
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